Showing posts with label tamoxifen. Show all posts
Showing posts with label tamoxifen. Show all posts

Wednesday, May 27, 2020

Home remedies can work but beware side effects

Breast cancer prescription might lessen pain for those without the disease, Mayo Clinic suggests


Tamoxifen, a prescription drug used for breast cancer treatment and prevention, can also lessen breast tenderness for those without the disease.

The problem, of course, is that there are potential "side effects that may be more bothersome than the breast pain itself."

That information is part of a laundry list of pain remedies suggested by the Mayo Clinic News Network.

Home remedies on the list may be effective, the network says, despite their being little research about their efficacy.

Furthermore, a network story indicates, for "many women, breast pain solves on its own over time" so a sufferer "may not need any treatment" at all.

But methods worth trying, according to the non-bylined network article, include: putting hot and cold compresses on the tender breast; wearing a firm support bra, or a sorts bra during exercise; experimenting with relaxation therapy; limiting or cutting out caffeine; following a low-fat diet; and using over-the-counter meds such as Tylenol (acetaminophen) or Advil or Motrin (or virtually any other brand of ibuprofen).

The article also lists alternative medicines such as vitamins (Vitamin e) and dietary supplements (evening primrose oil).

Checking with your physician before attempting any of the above remedies is highly recommended — in regard to risks and whether the self-care treatments are appropriate for you, as well as for approved dosages.

According to the article, treatments by doctors might include topical non-steroidal anti-inflammatories, an adjustment of birth control pills, a reduction of menopausal hormone therapies, or a prescription medication (the aforementioned Tamoxifen or Danazol).

More information on treating pain and disease can be found in "Rollercoaster: How a man can survive his partner's breast cancer," a VitalityPress book that I, Woody Weingarten, aimed at male caregivers.

Sunday, September 22, 2019

Breast cancer split into 11 separate diseases

'Molecular wiring' of tumors might forecast survival or relapse, new study shows


Can the so-called "internal wiring" of breast cancer predict whether you will survive or face a relapse?

The answer is a definite maybe.

As reported recently by the BBC News website, a new study published in the journal Nature indicates that the malady is actually 11 separate diseases with each having "a different risk of coming back [and] each with a different cause and needing different treatment." 

The article by health and science correspondent James Gallagher says that scientists at Stanford Universities and the University of Cambridge "looked in incredible detail at nearly 2,000 women's breast cancers" and analyzed the genetic mutations inside the tumors so they could "create a new way of classifying them."

Doctors, the piece notes, "currently classify breast cancers based on whether they respond to the hormone estrogen or targeting therapies like Herceptin."
Professor Carlos Caldas
Gallagher's story quotes Professor Carlos Caldas of the Department of Oncology at Cambridge Institute to the effect that the findings — which focus on the "molecular wiring" of the tumors — are "a very significant step to more precision-type medicine.

The study also "showed that triple negative breast cancers — one of the hardest to treat — were not all one class of cancer, but two."

The first group, according to the story, is "one where if women have not relapsed by five years they are probably cured" but a second subgroup is one in which women "are still at significant risk of later relapse."

Four subgroups, the article continued, "were both driven by estrogen and had a 'marked increased' risk of recurrence" — situations where patients "may benefit from a longer course of hormone therapy drugs like tamoxifen."

More information on research regarding the disease can be found in "Rollercoaster: How a man can survive his partner's breast cancer," a VitalityPress book that I, Woody Weingarten, aimed at male caregivers.

Tuesday, June 12, 2018

Are toxic treatments a thing of the past?

Many early-stage breast cancer patients may now skip chemo, new study's docs indicate


Lots of women with early-stage forms of breast cancer don't need chemotherapy.

At least that's the bottom line of a major international study, according to a recent report by Denise Grady in The New York Times.

Dr. Ingrid A. Mayer
Grady quotes Dr. Ingrid A. Mayer of Vanderbilt University Medical Center, an author of the study, as saying, "We can spare thousands and thousands of women from getting toxic treatment that really wouldn't benefit them. This is very powerful. It really changes the standard of care."

Instead of chemo, the study found, some women could "take only a drug that blocks the hormone estrogen or stops the body from making it."

That drug, tamoxifen, and related medicines "have become an essential part of treatment for most women," Grady's article says, "because they lower the risks of recurrence, new breast tumors and death from the disease."

The findings, which refer to that alternative endocrine therapy, apparently apply to about 60,000 women a year in the United States, according to Dr. Joseph A. Sparano of Montefiore Medical Center in New York, the study's leader.

The Times quotes Sparano as saying that "now we can spare chemotherapy in about 70 percent of patients who would be potential candidates for it based on clinical features."

But, the story adds, both Mayer and Sparano say women 50 and younger "might benefit from chemo even if gene-test results suggest otherwise. It is not clear why. But these women require especially careful consultation, they said."

The study, called TAILORx, was published in The New England Journal of Medicine and presented at a Chicago meeting of the American Society of Clinical Oncology. It was started in 2006 and was paid for by the U.S. and Canadian governments and philanthropic groups.

After 2016, Genomic Health, the company that makes the gene test Oncotype DX Breast Cancer Assy, the one most used in the United States, helped pay for it.

The test, available since 2004, costs about $3,000, and insurance usually covers it.

Some 260,000 new cases of breast cancer are expected in women in the United States this year, and 41,000 deaths. Globally, according to the Times, "the most recent figures are from 2012, when there were 1.7 million new cases and more than half-a-million deaths."

Chemo, long feared because of nausea and hair loss, puts patients at risk for infection and leukemia later in life. But endocrine therapy also has side effects. According to Grady, they include "hot flashes and other symptoms of menopause, weight gain and pain in joints and muscles."

Tamoxifen can increase the risk of cancer of the uterus, the story notes.

Despite the discomforts and risks, women with breast cancer have been getting chemo since 2000, when the National Cancer Institute recommended it even for those whose disease had not spread to lymph nodes "based on studies showing it could prevent the cancer from recurring elsewhere in the body and becoming incurable."

Sparano contends, however, that although "recurrences were being prevented, and lives prolonged…we were probably overtreating a lot of these women."

Mayer admitted that "we couldn't figure out who we really needed to treat."

More details on studies about the disease, treatments and risks can be found in "Rollercoaster: How a man can survive his partner's breast cancer," a VitalityPress book I, Woody Weingarten, aimed at male caregivers.

Wednesday, February 11, 2015

'Rollercoaster' full of resources, asserts blogger

Zealous writer: 'Rollercoaster' can make cancer diagnosis 'a little bit easier on us all' 


M.J. Joachim
M.J. Joachim is a "very passionate" author and writer from Mesa, Arizona.

A fellow blogger, Philip Verhese Ariel, explains that her passion, in part, has been aimed at "making the world a better place…by raising awareness."

One small step toward that goal, I'm absolutely thrilled to report, occurred when she gave my new VitalityPress book, "Rollercoaster: How a man can survive his partner's breast cancer," a glowing review.

Below, starting with the next paragraph, are excerpts from M.J.'s piece, which was published on Feb. 3, 2015. The full review, of course, is available on her website.

Breast cancer is one of those scary, taboo subjects nobody wants to talk about, despite the fact that millions of people are and have been affected by it. 

It’s personal. Cancer always seems to be so darned personal. 

For decades we’ve danced around the big C word. 

Until now! 

How I wish this book had been around when my father and uncles died of cancer so many years ago! How I wish this book had been around over the years when I had two benign breast biopsies - one at 28, another in my mid 30’s.

Weingarten is the caregiver of his wife Nancy and her breast cancer; years later, he is also the patient with cancer. 

Seems many of us get to deal with the big C more than once in our lives, and in various ways too. 

For all the research, money raised, government programs, medicines and treatments tried, things which Weingarten fully addresses in this book, we still don’t seem to find the answers we need. 

This book doesn’t offer any false hope. Weingarten describes in scrupulous detail the evolution of cancer meds and treatments since the 70’s. It’s an important section in the book, and if I ever do get cancer, you can bet I’ll never opt to take tamoxifen, partly because of what I learned in this book.

All the big C talk aside, Rollercoaster is a love story about a man and a woman dealing with her diagnosis, treatment and side effects (those little things no one really wants to talk about like loss of sex drive, anger and anxiety, relationship challenges, an entire myriad of fears ranging from how to deal with hair loss to night sweats and coping with nightmares, even eating to deal with stress)

Twenty years later Woody & Nancy are still happily married survivors of the big C that changed and redefined their lives forever. 

Marin-Man-to-Man is a drop-in, dues-free support group open to any male whose partner has or has had, breast cancer (or another life-threatening disease).” Much of this book makes reference to this excellent resource and support group for male caregivers living in the San Francisco Bay Area, a group Woody himself attends. 

Closing chapters are full of valuable resources and books for both caregivers and cancer sufferers alike. 

If you haven’t personally been touched by cancer yet, you’re lucky. I strongly recommend this book to everyone, because this book has the ability to make the dreaded big C diagnosis a little bit easier on us all.

Thanks so much for taking time to share your story, Woody. I trust and hope many people will be extremely fortunate to read Rollercoaster and benefit from you and your wife’s experience with breast cancer.

Tuesday, November 4, 2014

No. 1 book buyer survived breast cancer HIMself

First 'Rollercoaster' purchaser is male breast cancer survivor and a support group advocate


The very first buyer of my book, "Rollercoaster: How a man can survive his partner's breast cancer," was somewhat of a surprise.

He wasn't a caregiver for his wife. He was a breast cancer patient himself.

One of the unlucky 1 percent.

Gerry Bourguignon, a regular member of the support group that I, Woody Weingarten, have been leading almost 20 years, tells on our website — www.Marin-Man-to-Man.org — of his finding an early-stage small lump in his right breast in 2009.
Gerry Bourguignon

A biopsy showed that surgery, a modified mastectomy, was necessary to remove the tumor.

Eighteen months later, he stopped taking the post-surgical med tamoxifen — it's usually recommended for five years — because of "increasingly painful side effects [that] are generally worse for men compared to women."

But he felt okay — physically.

He needed support, however, and that's why he joined (and still attends) our group.

Gerry, a PhD and retired college prof who splits his time between homes in Pollock Pines and Mill Valley, California, is now on the board of directors of the To Celebrate Life Breast Cancer Foundation — www.tocelebratelife.org — an agency that since 1996 has granted more than $4 million to fund emergency and direct services for breast cancer patients.

Its basic mission is to raise money and give financial aid to other nonprofits that help people living with the disease.

Only 1 percent of all breast cancers occur in men — about 2,400 are diagnosed in the United States annually. That compares with nearly 250,000 women, which translates into roughly one every two minutes.

More than 2 million stateside women live with the chronic disease, and about 40,000 die of it each year.

Daunting statistics, perhaps.

But, as I note in "Rollercoaster," we all must remember that "each person is an individual, not a statistic (and that breast cancer couldn't care less about race, creed, sexual orientation or politics)."

Or, in fact, gender.