Showing posts with label survival. Show all posts
Showing posts with label survival. Show all posts

Sunday, September 22, 2019

Breast cancer split into 11 separate diseases

'Molecular wiring' of tumors might forecast survival or relapse, new study shows


Can the so-called "internal wiring" of breast cancer predict whether you will survive or face a relapse?

The answer is a definite maybe.

As reported recently by the BBC News website, a new study published in the journal Nature indicates that the malady is actually 11 separate diseases with each having "a different risk of coming back [and] each with a different cause and needing different treatment." 

The article by health and science correspondent James Gallagher says that scientists at Stanford Universities and the University of Cambridge "looked in incredible detail at nearly 2,000 women's breast cancers" and analyzed the genetic mutations inside the tumors so they could "create a new way of classifying them."

Doctors, the piece notes, "currently classify breast cancers based on whether they respond to the hormone estrogen or targeting therapies like Herceptin."
Professor Carlos Caldas
Gallagher's story quotes Professor Carlos Caldas of the Department of Oncology at Cambridge Institute to the effect that the findings — which focus on the "molecular wiring" of the tumors — are "a very significant step to more precision-type medicine.

The study also "showed that triple negative breast cancers — one of the hardest to treat — were not all one class of cancer, but two."

The first group, according to the story, is "one where if women have not relapsed by five years they are probably cured" but a second subgroup is one in which women "are still at significant risk of later relapse."

Four subgroups, the article continued, "were both driven by estrogen and had a 'marked increased' risk of recurrence" — situations where patients "may benefit from a longer course of hormone therapy drugs like tamoxifen."

More information on research regarding the disease can be found in "Rollercoaster: How a man can survive his partner's breast cancer," a VitalityPress book that I, Woody Weingarten, aimed at male caregivers.

Sunday, March 25, 2018

New drugs can lead to 'varied, bizarre' problems

Cancer-killing immunotherapies can cause major side effects in otherwise healthy organs


New immunotherapies can eliminate cancers but may also cause big problems with healthy body organs. 

According to a recent story by Laurie McKinley in The Washington Post, the perplexing side effects can range from inconsequential to severely dangerous, even life-threatening.

The article cites the case of a 55-year-old patient whose therapy "knocked back her cancer [but] also gave her 'almost every 'itis' you can get'… arthritis-like joint pain, lung inflammation called pneumonitis and liver inflammation that bordered on hepatitis."

The woman, McKinley's piece continues, warns "that highly touted immunotherapy treatments have downsides as well as benefits and to watch for complications, because 'not all doctors know all the side effects.'"

The upside is clear, however.

Checkpoint inhibitors, the new therapies, "offer a tantalizing chance for survival for patients with advanced melanoma and hard-to-treat cancers of the bladder, kidney and lung," the story says.

The downside? 

"The treatments, designed to unleash the immune system to attack malignancies, also can spur an assault on healthy organs, causing varied and bizarre side effects ranging from minor rashes and fevers to diabetes and deadly heart problems."
Dr. Drew Pardoll

Some of the symptoms, unfortunately, can fool doctors because they "can mimic those of the flu, infections or even food poisoning. That lack of awareness [by physicians] can be dangerous, given that quick intervention is the key to preventing serious damage."

The Post article quotes Dr. Drew Pardoll, director of the Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University, as noting that immunotherapy "has a completely different side-effect profile than chemotherapy, and that has caught some physicians off guard."

Doctors, including emergency-room physicians, dermatologists and gastroenterologists, Pardoll insists, "need to go back to school" to earn about immunotherapy.

The side effects, McKinley writes, "occur in 15 to 70 percent of immunotherapy patients, depending on which drug is used and whether the medications are used individually or combined with one another or conventional cancer treatments."'

Are the cancer treatments worth using despite the side effects?

According to Kevan Herald, an immunologist and endocrinologist at Yale University, they absolutely are. "If it's a choice between staying alive and developing diabetes versus not, I'd always pick taking the drug and managing the diabetes."

Jeffrey Bluestone, an immunologist at the University of California, San Francisco, is also quoted in the Post piece. "The last thing you want to do is scare people away from lifesaving treatments," he maintains.

Questions about new treatments, drugs and research on life-threatening diseases are addressed in "Rollercoaster: How a man can survive his partner's breast cancer," a VitalityPress book I, Woody Weingarten, aimed at male caregivers.

Thursday, October 1, 2015

'Rollercoaster' author to speak at Novato men's breakfast club about being a male caregiver



Woody Weingarten
I, Woody Weingarten, have been running a weekly men's support group — Marin Man to Man — for 20 years. 

It's mainly for guys whose partners have, or had, breast cancer.

Tomorrow, Friday, Oct. 2, I get to talk to a different men's group about those years — and about my being the prime caregiver for my wife, Nancy Fox, who was diagnosed with breast cancer two decades ago and lived through the requisite "slash, poison and burn" treatments — surgery, radiation and chemotherapy.

And how she's thriving today.

I'll also speak about my VitalityPress book, "Rollercoaster: How a man can survive his partner's breast cancer."

Tomorrow's talk will be at the weekly 7 a.m. North Marin Breakfast Club in Novato, and is expected to draw some 40 men, including many of the county's leaders.

I'm pleased to have the opportunity.

Sunday, February 1, 2015

'Rollercoaster' author provides own Fantasyland

Writer flaunts wish on Texan's blog: 35 million to buy and read 'Rollercoaster,' dispel worries


Welcome to Fantasyland, Woody Weingarten version, circa 2015.

During an interview just published online, I implied that if most of the 35 million caregivers in the United States bought my new VitalityPress book, "Rollercoaster: How a man can survive his partner's breast cancer," I'd stop worrying "about getting out my message that there can be light and life at the end of the proverbial tunnel."
Maryann thinks photo shows my message.
Probably true.

But my late mother's DNA legacy, a throbbing worry gland, might not let me off the hook so easily.

The interview, which went online last Wednesday, Jan. 28, was carried out by Texas blogger, columnist, novelist and  playwright Maryann Miller. It marked my initial dip into somebody else's pool.

It was fun to do.

Here is the lion's share of the interview (for the whole enchilada, check out Maryann's blog, "It's Not All Gravy").  

Hi, Woody here. I’m thrilled to be interviewed/interrogated by Maryann, but I must admit I’m a little nervous. Although I’m a chronological geezer, I’m actually a virgin — at appearing on someone else’s blog, that is.

LOL, Woody, that’s the best introduction I’ve had from one of my guests. And now that you are no longer a virgin at this, I do hope you will find other blogs on which to do a guest post.

Q. Please tell our readers how you came to write your latest book.

I wrote “Rollercoaster” because I believed my experiences, research and expertise could help those going through a life-threatening disease or its aftermath. I think male caregivers, often the forgotten part of the breast cancer equation, are particularly in need of help. But women also can learn what their partners may be feeling. According to The New York Times, there currently are 35 million caregivers in the United States. If most of them bought “Rollercoaster,” I’d be able to stop worrying about getting out my message that there can be light and life at the end of the proverbial tunnel.

Q. You have been through the ordeal of having a spouse with breast cancer twice. Did the fact that your first wife had it, make it harder when Nancy was diagnosed?

In a word, yes. It was incredibly sad, and frightening, when the mother of my children ultimately died from the disease. But the fear has faded over time, and Nancy, I’m happy to report, is alive and thriving 20 years later.

Q. There was a lot in the book about chemo-brain, and I know from my sister’s experience that the memory loss is a problem. Did Nancy find that her memory improved after being past chemo for some time?

Nancy’s memory did get better, but there still are blanks and blotches that apparently will never improve. And of course I’m convinced that, like many otherwise loving wives, she’ll never completely forget anything I ever did wrong. (Don’t take that sentence seriously. Now and then she even lets go of my sins.)

Q. What is the hardest thing about writing?

Writing. That’s meant to be a half-joke, and it’s mostly untrue. The hardest part is rewriting and rewriting and rewriting to “get it right.”

Amen to that!!

Q. What is the most unusual or interesting research you have done for your books?

The most interesting by far was discovering that almost any medical findings, no matter how definitive a report seemed, are likely to be contradicted by other research in the following weeks, months or years. The pendulum keeps swinging back and forth, confusing practitioners, patients and caregivers.

That was equally interesting to me as a reader, too, Woody, as was the chapter on medications.

Q. What is your fondest childhood memory?

Believe it or not, it’s a cumulative memory consisting of a series of accidents. I was hit by a moving car while playing ball in the street. I fell off a school wall into a tree limb that pierced my chest. I cut my knee when I recklessly stepped through the windshield of a tractor-trailer that was sitting, shattered, on the ground. The reason it’s my “fondest” memory is simple — I survived.

And we are so glad you did, Woody.

Q. If you could go through a wormhole, would you go into the future, the past, or stay right here? Why?

I’d stay right here. I’m mature enough to have learned more than a thing or two about “giving back” and enjoying life without being too old to make those things happen.

Great thought with which to end the interview, Woody. As you say in your book, looking mortality in the face does give you a new perspective on life. Thanks so much for being my guest today.

BOOK BLURB: 
"Rollercoaster" a comprehensive memoir-chronicle and guide to up-to-the-minute scientific research, meds and where to get help. It shows how Nancy Fox and her husband Woody Weingarten coped with breast cancer, its treatments and its aftermath — and how you can as well. Almost 250,000 new breast cancer cases are diagnosed annually. Male caregivers (husbands, boyfriends, fathers, sons and brothers) typically become a forgotten part of the equation. Yet they, too, need support. “Rollercoaster” can help provide it. Weingarten, a prize-winning journalist for 50 years, has led a male partner’s support group for two decades. Though he became an expert reluctantly, he now unflinchingly shares what he’s learned.

You can connect with Woody at his weblog on Facebook and Twitter
and LinkedIn

COMMENTS:
LD Masterson: Very nice meeting Woody. I wish this book had been available when my dad was taking care of my mom.

Maryann Miller: 
Thanks for stopping by, LD. I, too, wish the book had been available when my sister went through her surgery and treatment.